Does past or present depression differentiate Lewy body from Alzheimer disease?
نویسندگان
چکیده
منابع مشابه
Does past or present depression differentiate Lewy body from Alzheimer disease?
Clinical differentiation of Lewy body disease (LBD) from Alzheimer disease (AD) is still problematic. Many persons with LBD lack the cardinal features of visual hallucinations, fluctuations in cognition, and mild Parkinsonism proposed by McKeith et al. (2005). Some studies suggest that history or presence of depression may help distinguish LBD from AD, but this is confounded because many clinic...
متن کاملAlzheimer and Lewy body pathology or Creutzfeldt-Jakob disease.
The objective of this work is to describe the neuropathological findings of a patient clinically presenting with rapidly progressive nonspecific neurological symptoms suggestive of Creutzfeldt-Jakob disease. Methods used were clinical description with laboratory analyses, repeated electroencephalogram, cerebral computed tomography, magnetic resonance imaging studies and details on neuropatholog...
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Cortical Lewy body disease as a cause of dementia has been recognized for more than 40 years. Only in the past 15 to 20 years, however, has the true frequency of this entity come to be appreciated, primarily because of the advent of sensitive and specific immunohistochemical diagnostic techniques. We now know that there is frequent and extensive overlap, both clinically and pathologically, betw...
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BACKGROUND Reductions in cholinergic function occur in Alzheimer disease (AD) and dementia with Lewy bodies and correlate with cognitive decline. However, whether such alterations appear in early-stage disease is unclear. OBJECTIVE To examine the timing of cholinergic deficits in AD and dementia with Lewy bodies. METHODS Autopsy series of 89 patients with AD and 50 patients with the Lewy bo...
متن کاملPersonality traits distinguishing dementia with Lewy bodies from Alzheimer disease.
OBJECTIVE To identify personality traits that distinguish dementia with Lewy bodies (DLB) from Alzheimer disease (AD). METHODS We examined 290 participants enrolled in a longitudinal study (nondemented control = 34, DLB = 128, AD = 128) followed to autopsy. As part of the annual interview with the collateral source, the clinician asked about specific changes in personality, interests, and dri...
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ژورنال
عنوان ژورنال: International Psychogeriatrics
سال: 2014
ISSN: 1041-6102,1741-203X
DOI: 10.1017/s1041610214001793